When You’re on an IUD and Antidepressants: Why You Might Feel Off — and How to Rebuild Your Foundation

Many women rely on both an IUD for birth control and an antidepressant for mental health support. These medications can be life-changing — giving you freedom, stability, and peace of mind. But if you’ve noticed new symptoms like fatigue, irritability, low motivation, or gut discomfort, you’re not alone.

There’s growing evidence that both hormonal IUDs and antidepressants can deplete key nutrients and alter gut health — two factors that play a major role in how you feel, think, and show up every day.

Let’s break down what’s happening inside your body — and how you can support it from the inside out.

Hormonal IUDs: What’s Really Going On

Most hormonal IUDs (like Mirena®, Kyleena®, or Liletta®) release a synthetic form of progesterone called levonorgestrel.
While it’s highly effective for birth control, this synthetic hormone can also:

• Disrupt your natural hormone rhythm

• Increase inflammation and oxidative stress

• Deplete mood-supporting nutrients such as:

  • Magnesium (calms the nervous system)

  • B6 and B12 (needed for serotonin and dopamine)

  • Zinc and Selenium (support thyroid and mood regulation)

  • Vitamin C and D (support immune and neurotransmitter health)

Over time, this depletion can leave you feeling drained, anxious, or emotionally flat — even when life seems “fine.”

Antidepressants: Another Layer of Depletion

Now add antidepressants (SSRIs, SNRIs, or tricyclics) to the mix. These medications help boost serotonin or norepinephrine in the brain, but they can also:

• Impair nutrient absorption in the gut

• Decrease levels of CoQ10, B-vitamins, magnesium, and zinc

• Alter the gut microbiome, which plays a crucial role in mood regulation

So, while your IUD and antidepressant are both working toward hormonal and emotional stability, they may also be quietly depleting the very nutrients that create a stable mood and steady energy in the first place.

When Both Overlap: The Perfect Storm for Fatigue and Mood Swings

When you’re using both an IUD and an antidepressant, your body faces a double depletion effect.
Low magnesium + low B-vitamins + disrupted gut =
→ poor neurotransmitter synthesis
→ slower energy production
→ higher stress sensitivity

This often shows up as:

• Persistent tiredness or low motivation

• Feeling “off” or emotionally numb

• Sleep changes or digestive issues

• Heightened PMS-like symptoms

It’s not in your head — it’s in your cells.

Rebuild What’s Missing: The Alii Approach

Alii Supplements was designed for this exact intersection — where women’s hormonal and mental health meet nutrient science.

Here’s how Alii helps rebalance your body naturally:

1. Replenishes Depleted Nutrients

   • B-vitamins restore energy production and support serotonin and dopamine.

   • Magnesium and CoQ10 enhance mitochondrial function for steady energy.

   • Zinc, Selenium, and Vitamin D nourish thyroid and immune health.

   • Vitamin C combats oxidative stress from both medications.

2. Restores the Gut–Brain Connection

   • Alii contains Corebiome™ tributyrin, a clinically studied postbiotic that helps rebuild the gut microbiome.

   • A balanced microbiome improves nutrient absorption, supports serotonin production (nearly 90% of which is made in the gut!), and stabilizes mood.

3. Supports Resilience and Balance

   • By rebuilding your nutrient stores and strengthening your gut lining, Alii helps your body handle stress better — the foundation for long-term mood and energy health.

✨ Your Body Wants Balance

It’s empowering to know that your symptoms aren’t random — they’re signals.
Your body is asking for replenishment.

Whether you stay on your IUD, your antidepressant, or both, you can still give your body what it needs to function optimally.

By refilling those missing nutrients and restoring your gut health, you support:

• Sharper focus

• Brighter mood

• More natural energy

• Hormonal harmony

Final Thought

You deserve to feel balanced, energized, and clear — not just “okay.”

If you’re using an IUD and taking antidepressants, supporting your nutrient levels and microbiome isn’t optional; it’s essential.
That’s exactly what Alii was made for — to help you replenish what your medications take and give you back the vitality you were missing.

Because when your body has just the right nutrients, your mind and mood finally have the space to thrive.